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KMID : 1044520170800010045
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Tuberculosis and Respiratory Diseases
2017 Volume.80 No. 1 p.45 ~ p.51
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Incidence of Fever Following Endobronchial Ultrasound?Guided Transbronchial Needle Aspiration
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Kim Seo-Yun
Lee Jin-Woo
Park Young-Sik
Lee Chang-Hoon
Lee Sang-Min
Yim Jae-Joon
Kim Young-Whan
Han Sung-Koo
Yoo Chul-Gyu
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Abstract
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Background: Endobronchial ultrasound?guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive diagnostic method for mediastinal and hilar lymphadenopathy. This study aimed to investigate the incidence of fever following EBUS-TBNA.
Methods: A total of 684 patients who underwent EBUS-TBNA from May 2010 to July 2012 at Seoul National University Hospital were retrospectively reviewed. The patients were evaluated for fever by a physician every 6?8 hours during the first 24 hours following EBUS-TBNA. Fever was defined as an increase in axillary body temperature over 37.8℃.
Results: Fever after EBUS-TBNA developed in 110 of 552 patients (20%). The median onset time and duration of fever was 7 hours (range, 0.5?32 hours) after EBUS-TBNA and 7 hours (range, 1?52 hours), respectively, and the median peak body temperature was 38.3℃ (range, 37.8?39.9℃). In most patients, fever subsided within 24 hours; however, six cases (1.1%) developed fever lasting longer than 24 hours. Infectious complications developed in three cases (0.54%) (pneumonia, 2; mediastinal abscess, 1), and all three patients had diabetes mellitus. The number or location of sampled lymph nodes and necrosis of lymph node were not associated with fever after EBUS-TBNA. Multiple logistic regression analysis did not reveal any risk factors for developing fever after EBUS-TBNA.
Conclusion: Fever is relatively common after EBUS-TBNA, but is transient in most patients. However, clinicians should be aware of the possibility of infectious complications among patients with diabetes mellitus.
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KEYWORD
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Endoscopic Ultrasound-Guided Fine Needle Aspiration, Fever, Infection
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